The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to orthostatic stress.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
78
Lower limbs are put in in LBNP device for one hour (-30 mbar)
candesartan cilexetil 16 mg once a day for 7 days cross over with placebo in control group, obesisty group and white coat hypertension group
Service of nephrology and hypertension
Lausanne, Canton of Vaud, Switzerland
Service of nephrology and hypertension
Lausanne, Switzerland
sodium excretion
sodium excretion will be compared to control group (healthy volunteers) after one hour of lower negative pressure. The protocol includes 2 hours of baseline measure, one hour of lower negative pressure and 2 hours of recovery
Time frame: after one hour of lower body negative pressure
glomerular filtration rate
Time frame: after one hour of lower body negative pressure
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