Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells

Nantes University Hospital20 enrolled

Overview

The recent developments of research on iPS (induced pluripotent stem) cells lead to the establishment of mature cell lines such as cardiomyocytes or valvular interstitial cells with genetic and cellular characteristics of the donors. These cells represent a biological material more readily available to identify the pathophysiological mechanisms involved in the diseases of BrS or ERS patients, which will lead to the identification of genetic markers.

Study Type

INTERVENTIONAL

Masking

NONE

Enrollment

Conditions

Inherited Arrhythmias and Valvulopathies

Interventions

Skin biopsiesOTHER

Eligibility

Sex: ALLMin age: 22 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * Patient with a family history of inherited arrhythmia or valvulopathy * Age : 22-60 yo. * patient no confine to bed * Male or female * Written consent * Patient affiliated to the French social security Exclusion criteria: * Pregnant woman * Patient under 22 yo or adults under guardianship * Indication against local anesthesia * Anticoagulant treatment * Absence or positivity of HIV, HBV, HCV serology

Locations (1)

Nantes University Hospital

Nantes, France

Outcomes

Primary Outcomes

Production of cardiomyocytes modele from skin fibroblast of arrhythmic patient

Secondary Outcomes

Production of valve interstitial cells modele from skin fibroblast of patient with a valvulopathy

Data from ClinicalTrials.gov

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