Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy

Inclusion Criteria: * •Male and female subjects with CD20+ B cell malignancies in patients with no available curative treatment options (such as autologous or allogeneic SCT) who have limited prognosis (several months to \< 2 year survival) with currently available therapies will be enrolled * CD20+ leukemia or lymphoma * ALL in CR2 or CR3 and not eligible for allogeneic SCT because of age, comorbid disease, or lack of available family member or unrelated donor * Follicular lymphoma, previously identified as CD20+: * At least 2 prior combination chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy * Stage III-IV disease * Less than 1 year between last chemotherapy and progression (i.e. most recent progression free interval \< 1 year) * Disease responding or stable after most recent therapy (chemotherapy, MoAb, etc) * CLL: * At least 2 prior chemotherapy regimens (not including single agent monoclonal antibody (Rituxan) therapy. Patients with high risk disease manifested by deletion chromosome 17p will be eligible if they fail to achieve a CR to initial therapy or progress within 2 years of 1 prior * Less than 2 years between last chemotherapy and progression (i.e. most recent progression free interval \< 2 years) * Not eligible or appropriate for conventional allogeneic SCT * Patients who achieve only a partial response to FCR as initial therapy will be eligible. * Mantle cell lymphoma: * Beyond 1st CR with relapsed or persistent disease and not eligible or appropriate for conventional allogeneic or autologous SCT * Disease responding or stable after most recent therapy (chemotherapy, MoAb, etc...) * Relapsed after prior autologous SCT * B-cell prolymphocytic leukemia (PLL) with relapsed or residual disease after at least 1 prior therapy and not eligible for allogeneic SCT * Diffuse large cell lymphoma, previously identified as CD20+: * Residual disease after primary therapy and not eligible for autologous SCT * Relapsed after prior autologous SCT * Beyond 1st CR with relapsed or persistent disease and not eligible or appropriate of conventional allogeneic or autologous SCT * Expected survival \> 12 weeks * Creatinine \< 2.5 mg/dl * ALT/AST \< 3x normal * Bilirubin \< 2.0 mg/dl * Any relapse after prior autologous SCT will make patient eligible regardless of other prior therapy * Adequate venous access for apheresis, and no other contraindications for leukapheresis * Voluntary informed consent is given Exclusion Criteria: * •Pregnant or lactating women * The safety of this therapy on unborn children is not known * Female study participants of reproductive potential must have a negative serum or urine pregnancy test performed within 48 hours before infusion * Uncontrolled active infection * Active hepatitis B or hepatitis C infection * Concurrent use of systemic steroids. Recent or current use of inhaled steroids is not exclusionary * Previously treatment with any gene therapy products * Feasibility assessment during screening demonstrates \< 30% transduction of target lymphocytes, or insufficient expansion (\< 5-fold) in response to CD3/CD28 costimulation * Any uncontrolled active medical disorder that would preclude participation as outlined * HIV infection