There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.
Study Type
OBSERVATIONAL
Enrollment
2,000
Karolinska Institutet, Ersta Hospital
Stockholm, Sweden
Karolinska Institutet, Danderyds Hospital
Stockholm, Sweden
Karolinska University Hospital
Stockholm, Sweden
Genetic markers
Blood samples and tissue biopsies taken at the time of surgery and at follow-up.
Time frame: day of surgery and 1 and 2 years after surgery
Lipid and protein patterns in plasma and tissues
Blood samples taken and tissue biopsies taken at the time of surgery and at follow-up
Time frame: day of surgery and at 1 and 2 years postoperatively
Previous viral infection
Blood samples taken before surgery
Time frame: At time of surgery
Genexpression and comorbid disease
Gene expression studies in tissue biopsies and whole blood at time of surgery and follow-up
Time frame: At time of bariatric surgery and 1-2 years postoperatively
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