Evaluation of Spectra Optia Red Blood Cell Exchange in Sickle Cell Patients

Inclusion Criteria: * At least 12 years old * Enrolled in a program of regular red blood cell exchange (RBCx) to prevent symptoms/complications of sickle cell disease (SCD) or Initiating a program of regular RBCx or Receiving RBCx as a pre-surgical procedure. * Medically stable * Previous documentation of diagnosis by hemoglobin electrophoresis of a type of sickle cell disorder requiring RBCx. * Sufficient vascular access to accommodate the RBCx procedure as determined by the apheresis technician performing the procedure or phlebotomist responsible for obtaining intravenous access. * Availability of sickle trait negative, leukoreduced, ABO blood group, Rhesus factor D (Rh (D)) compatible, unexpired replacement blood. See Glossary for definition of replacement blood. * Able to commit to the study follow-up schedule. * Agree to report adverse events (AEs) during the required reporting period. Exclusion Criteria: * Inability to obtain informed consent/assent from patient, or permission from parent or guardian. * Pregnancy (negative serum pregnancy test required for females of childbearing potential). * Life expectancy is fewer than 30 days from time of procedure. * Incarcerated or a ward of the court. * Refusal of blood products. * Failure to comply with site standard requirements for cessation of medications (e.g., angiotensin converting enzyme (ACE) inhibitors) that interfere with or increase risk of RBCx procedures. * History of drug or alcohol abuse that, in the opinion of the investigator, could affect the ability of the patient to comply with the study requirements Inability to comply with the protocol in the opinion of the investigator.