Efficacy and the Safety Study of RD94 in Patients With Endodontic Care

Inclusion Criteria * provide signed, informed consent. * be affiliated to social security. criteria for the corresponding indication: Direct pulp capping following carious pulp exposure - children (6 to 18 years) + adults * Symptomatic or asymptomatic mature or immature tooth that presented pulp exposure when scraping out carious lesions or performing cavity preparation. Direct pulp capping following dental trauma injury to healthy pulp, reformulated as a partial pulpotomy - children (6 to 18 years) + adults \- Permanent mature or immature single-root tooth having suffered traumatic injury \< 72 hours, with amelodentinal coronal fracture causing pulp exposure. Repairing perforated root canals and/or the pulp chamber floor - adults * Iatrogenic perforation of the pulpal floor, with or without LEO. * Iatrogenic perforated root canals following post space preparation involving dentin matrix, with or without LEO. * Iatrogenic perforated root canals with stripping not involving dentin matrix, with or without LEO. Retrograde endodontic surgery - adults * Failure of endodontic treatment or retreatment, evidenced by recent or persistent clinical or radiological signs of LEO and/or symptoms on a tooth in which the root canal filling looks to be of sufficiently good quality, provided that a working coronal restoration is in place. * Failure of endodontic treatment evidenced by recent or persistent clinical or radiological signs of LEO and/or symptoms on a tooth in which the root canal filling is inadequate, when orthograde retreatment does not offer a more favorable risk-benefit ratio than the surgery option. Pulpotomy in primary molars - children ( 3 to 12 years ) * Molar presenting deep carious lesion without irreversible pulpal disease, as the molar has to stay on the dental arch for at least 3 years. * Pulp exposure during excision of a carious lesion on a temporary molar that does not present irreversible pulp disease. The molar has to stay of the dental arch for at least 3 years. Apexification - children (7 to 18 years) + adults * Permanent immature single-root tooth having suffered periodontal or dentoalveolar injury causing pulp necrosis with or without periapical disease (LEO) in children, teenagers or adult patients. * Permanent immature single-root tooth presenting pulp necrosis with or without periapical disease (LEO) in children. * Apical Root Resorption Exclusion Criteria 1. History of malignancy in the last 5 years. 2. Systemic disease not stabilized within 1 month before the Inclusion Visit or judged by the investigator to be incompatible with the study or condition incompatible with the frequent assessments needed by the study. 3 Risk A cardiopathies 4. Known hypersensitivity to one of the components of the study or procedural medications. 5\. Presence or history of severe systemic allergy. 6. Presence or history of drug addiction or alcohol abuse. 7. Patient who has participated in a clinical trial with a new active substance during the month before study entry. 8\. Participation in another clinical study at the same time as the present study. 9\. Known pregnancy or lactation at study entry. exclusion criteria for each indication : Direct pulp capping following carious pulp exposure * Chronic irreversible pulpitis * Pulp necrosis * Anterior or saliva-contaminated tooth pulp exposure * Accidental exposure occurring during non-retentive prosthetic preparation Direct pulp capping following dental trauma injury to healthy pulp, reformulated as a partial pulpotomy * Pulp exposure period \> 72 hours * Crown-root fracture * Pulpal necrosis with or without periapical disease(LEO) Repairing perforated root canals and/or the pulp chamber floor * Supracrestal iatrogenic perforation * Inadequate periodontal support * Loss of tooth structure (Coronal decay and/or concomitant root decay) compromising the tooth's maintenance on the dental arch) Retrograde endodontic surgery * Failure of endodontic treatment or retreatment, evidenced by recent or persistent clinical or radiological signs of LEO and/or symptoms on a tooth in which the root canal filling looks to be of sufficiently good quality, when a working coronal restoration is either missing or presents microleakage * Failure of endodontic treatment evidenced by recent or persistent clinical or radiological signs of LEO and/or symptoms on a tooth in which the root canal filling is inadequate, when surgical treatment does not offer a more favorable risk-benefit ratio than the orthograde retreatment option * Insufficient periodontal support, endo-periodontal lesion * Coronal decay and/or concomitant root decay compromising the tooth's maintenance on the dental arch * Maxillary intrabony lesion of suspected non-endodontic origin Pulpotomy: * Temporary molar expected to begin exfoliation within 24 months. * Molar presenting signs of irreversible pulp disease - spontaneous pain