Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC)

Inclusion Criteria: * Age 4 through 65 years * Subject has a confirmed diagnosis of HbSS, HbSC, HbSβ+thal, or HbSβ0thal * Subject is experiencing acute pain typical of vaso-occlusive crisis requiring treatment with parenteral analgesia * Subject requires hospitalization Exclusion Criteria: * Subject has acute chest syndrome * Subject's laboratory results indicate inadequate organ function * Subject is pregnant or nursing an infant * Subject had a painful crisis requiring hospitalization within the preceding 14 days or has experienced \> 5 hospitalizations for VOC in the prior 6 months * Subject has been transfused within the past 14 days * Subject is hospitalized for a condition other than VOC * Subject has complications related to SCD