GLOBAL Clinical Study

Inclusion Criteria: 1. Ages 18-90 2. Caucasian and of Non-Hispanic or Non-Latino origin 3. Referral for coronary CT angiography to evaluate for presence of CAD 4. The patient has signed the appropriate Institutional Review Board approved Informed Consent Form Exclusion Criteria: 1. Immunosuppressive or immunomodulatory therapy including any dose of systemic corticosteroids in the preceding 30 days (except if steroids are administered as pre-medication prior to contrast administration for CT scan within 24 hours). 2. Chemotherapy in the preceding year 3. Major surgery in the preceding 2 months 4. Blood or blood product transfusion in the preceding 2 months 5. Subjects for whom coronary CT angiography is contraindicated per institutional standard of care 6. Subjects with previous coronary arterial revascularization (PCI or CABG) 7. Subjects with atrial fibrillation/flutter or frequent irregular or rapid heart rhythms, which occurred within the past 3 months 8. Subjects with a pacemaker or implantable cardioverter-defibrillator implant 9. Active congestive heart failure or the presence of known non-ischemic cardiomyopathy 10. Known genetic disorders of atherosclerosis, lipid or lipoprotein metabolism