Effect of Cheese on Cardiovascular Risk

University of Copenhagen19 enrolled

Overview

The main objective of the current study is to examine whether a high intake of regular-fat cheeses (Danbo and Cheddar) affect blood lipids differently than an isocaloric intake of either other fatty animal food products or of starchy carbohydrates. Furthermore, effects on fat digestibility, blood pressure, anthropometry, bile acid metabolism and insulin sensitivity is investigated. To do this, a randomized crossover intervention study with 3x14 days full diet periods (cheese diet, meat diet or carb diet)will be conducted in 16 postmenopausal women. Between the diet periods there will be at least 14 days of wash-out where the subjects eat their habitual diets. Fasting blood samples will be drawn before and after the diet periods, and also a non-fasting blood sample will be drawn after the diet periods. Furthermore, total feces is collected the last 5 days of each diet period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Hyperlipidemia

Interventions

Eligibility

Sex: FEMALEMin age: 45 YearsMax age: 68 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female gender * Postmenopausal for \>1 year * Age 45-68 years * BMI 25-32 kg/m2 * TC \> 4.5 mmol/L and \< 7 mmol/L * Systolic blood pressure \<160 mmHg and/or diastolic blood pressure \<100 mmHg Exclusion Criteria: * Chronic diseases (known diabetes; CVD; other chronic diseases which could affect the results of the present study) * Milk allergy * Nut allergy * Use of dietary supplements incl. multivitamins (2 months before and during the entire study period) * Smoking * Elite athletes (\>10 hours of strenuous physical activity per week) * Use of prescription medicine which could affect the results of the present study including systemic glucocorticoids * Use of lipid-lowering agents * Stable dose of antihypertensive medication \>3 months before study commencement for subjects with high blood pressure * Hormone replacement therapy * Blood donation \<1 month before study commencement and during study period * Simultaneous participation in other clinical studies * Inability (physically or psychologically) to comply with the procedures required by the protocol