Screening and Understanding of the Pre-diabetes: DECODIAB

Inclusion Criteria: * Adult patients (≥18 years) * Subjects with diabetes risk score ≥ 12 or with impaired fasting glucose: blood glucose ≥ 1.10 g/l and \< 1 .26 g/L * And with impaired fasting glucose : blood glucose ≥ 1.10 g/l and \< 1 .26 g/L ; or blood glucose ≥ 1g/l and \< 1,1 g/L WITH HbA1C ≥ 6,5% * Signed informed consent * Subjects affiliated with an appropriate social security system Exclusion Criteria: * Fasting glycemia ≥ 1.26 g/l * Fasting glycemia ≤ 1.10 g/l AND HbA1C \< 6,5% * Fasting glycemia \< 1 g/l * Subjects previously treated with oral anti-diabetic: metformin, glitazones, inhibitors of α-glucosidase, sulfonylurea, repaglinide, inhibitors of DPP-IV. * Subjects previously treated with insulin, except gestational diabetes * Severe coagulation disorders * Thrombocytopenia \< 100 000/mm 3 * Severe psychiatric disorders * Severe renal insufficiency (creatinine clearance \< 30 ml/min) * Severe hepatic insufficiency * Alcohol abuse (\> 30g/j) * Contra-indication in the realization of the local anesthetic * Subject unable to follow the study during the 5 years of follow-up * Subject exclusion period in a previous study