Urinary Biomarkers For Objective Measurement Of InterStim® Response In Over Active Bladder (OAB) Patients.

OAB subjects (n=10 Phase I and n=10 Phase II) Inclusion Criteria: * Female * Age 18-75 years * Clinical symptoms of OAB (urgency and frequency with or without urge incontinence) for at least 3 or the 6 months immediately before the first visit. * At least 8 voids/day and an average of 1 nocturnal void over 3 consecutive days on baseline bladder diary. * InterStim® treatment naïve or being revised with a new lead Exclusion Criteria: * Pelvic mass, pelvic prolapse, urinary retention, and pelvic malignancies as revealed by physical examination/medical record review * Implanted Programmable Generator (IPG) is not implanted/connected to the tined lead (failed Stage I) * Revision of only the IPG (without replacement of the tined lead) * More than one InterStim® device being placed (undergoing bilateral stimulation) Controls (n=10) Inclusion: * Female * Age 18-75 years * Deny history of OAB diagnosis or symptoms (urgency and frequency with or without urge incontinence) * American Urological Association (AUA) symptom score of ≤4 Exclusion: -History of pelvic mass, prolapse, urinary retention, or pelvic malignancy within the last year