Our hypothesis is that hypothyroid patients on DTE may have a decrease in symptoms, an improvement of cognitive function, and an increase in sense of well-being/ quality of life equivalently compared with L-T4.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
180
Levothyroxine in a capsule form, once daily, with appropriate dosage to keep TSH in the normal range.
Armour thyroid in a capsule form, once daily, with appropriate dosage to keep TSH in normal range.
Walter Reed National Military Medical Center, Endocrinology
Bethesda, Maryland, United States
ENROLLING_BY_INVITATIONWalter Reed National Military Medical Center
Bethesda, Maryland, United States
RECRUITINGthyroid-symptom questionnaire
Thyroid Symptom Questionnaire, a health-related quality-of-life questionnaire, that consists of 12 questions, presented in the same format as the GHQ-12, that asked patients how they felt over the last three months.
Time frame: 4 months
Wechsler Memory Scale-Version IV (WMS-IV)
The Wechsler Memory Scale-Version IV (WMS-IV) included auditory memory index, visual memory index, visual working memory index, immediate memory index and delayed memory index.
Time frame: 4 months
Biochemical measures
Biochemical testing consisting of serum TSH, free T4, total T4, total T3, T3 resin uptake, sex hormone binding globulin (SHBG), and a lipid panel.
Time frame: 4 months
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