Biological Potency of the Cat Epithelial Allergenic Extracts

Inclusion Criteria: A subject will be eligible for inclusion in the study only if all of the following criteria are met: * The subject (and/or legal representative, where applicable) has given written, signed and dated informed consent. * Subjects of either sex and of any race or ethnic group. * Age \> 18 years and \< 60 years on the day of inclusion in the study. * Positive clinical history of allergy to cat epithelia (i.e., rhinitis, conjunctivitis, rhinoconjunctivitis, asthma, urticaria, etc. ). * A positive prick-test (mean diameter of papule ≥ 3 mm or area of papule ≥ 7 mm2) with a commercial extract of cat epithelium. The results of the prick-test will be valid if they were obtained in the year prior to inclusion of the subject in the study. * A positive specific IgE test (\> 0.70 KU/l) for cat epithelium. The results of the IgE test will be valid if they were obtained in the year prior to inclusion of the subject in the study. Exclusion Criteria: A subject will NOT be eligible for inclusion in the study if any of the following criteria are met: * Immunotherapy in the last 5 years involving allergens known to be able to interfere with the test allergen (e.g., cat extract). * Use of drugs that can interfere with the skin response before and during the study (e.g., antihistamines), within the intervals established in section 9.1 and appendix 1. * Treatment with any of the following medicines: tricyclic or tetracyclic antidepressants or MAOIs (Monoamine oxidase inhibitors), beta-blockers or chronic use of oral corticosteroids or use of corticosteroids via either the oral or the parenteral route in repeated and intermittent dosing regimens (\> 10 mg/day of prednisone or equivalent). * Pregnant or nursing women and women with a positive pregnancy test in visit 2. * Dermographism affecting the skin of the test site, in either of the two visits to the study centre. * Atopic dermatitis affecting the skin of the test site, in either of the two visits to the study centre. * Urticaria affecting the skin of the test site, in either of the two visits to the study centre. * Clinically relevant immune system diseases (both autoimmune disorders and immune deficiencies). (Hashimoto's thyroiditis with hypothyroidism well controlled through thyroid hormone therapy does not necessarily represent a contraindication. Graves' disease (hyperthyroidism) would be an exclusion criterion due to the potential risk in the event adrenaline must be used.) * Serious uncontrolled diseases that may increase the safety risk of the subjects participating in the study, including but not limited to the following: heart failure, serious or uncontrolled respiratory diseases, endocrine disorders, clinically relevant liver or kidney diseases, or haematological disorders. * Patents with diseases or conditions that limit adrenaline use (coronary disease, severe arterial hypertension, etc.). * Serious psychiatric, psychological or neurological problems. * Medication, alcohol or illegal drug abuse in the last year. * Participation in any other clinical trial during the 30 days (or 5 times the biological half-life of the investigational product - whichever is longest) prior to inclusion of the subject in this study.