Treatments for the macroscopic or pathologic lesions caused by HPV infection can be classified as topical, surgical, destructive, or immunomodulatory. Post surgical treatments generally consist of analgesic, anti-inflammatory and topical antimicrobial agents to reduce the risk of local infections. The aim of this study is to compare the efficacy and safety of polyhexamethylene biguanide-based vaginal suppositories to a similar chlorhexidine-based treatment, in the post recovery regimen after surgical treatment of cervical lesions. Women who underwent to CO2 laser therapy for cervical lesions are randomly assigned to receive 10 days of antiseptic treatment with chlorhexidine digluconate vaginal suppositories, or polyhexamethylene biguanide vaginal suppositories (Monogin® / BiguanelleTM vaginal suppositories, Lo.Li.Pharma, Italy). A weekly follow-up check was performed for 6 weeks.
Study Type
INTERVENTIONAL
AGUNCO
Rome, Italy
Bacterial vaginosis
Diagnosis of eventual bacterial infection is performed according to Amsel's criteria
Time frame: After three weeks by the day of the laser treatment
Change from baseline bleeding at 6 weeks
Visual scoring was assessed depending on the grade of the defect (from 1 to 3)
Time frame: At weekly intervals by the day of laser treatment
Change from baseline healing process at 6 weeks
Visual scoring for healing is assessed depending on the grade of the defect (from 1 to 3)
Time frame: At weekly intervals by the day of laser treatment
Change from baseline irritation status at 6 weeks
Visual scoring for irritation is assessed depending on the grade of the defect (from 1 to 3)
Time frame: At weekly intervals by the day of laser treatment
Bacterial vaginosis
Diagnosis is performed according to the Amsel's criteria
Time frame: After six weeks by the day of laser treatment
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