Comparison of Low-volume PEG Plus Ascorbic Acid Versus Standard PEG Solution as Bowel Cleansing for Colonoscopy

Dong Il Park, M.D, Ph.D.360 enrolled

Overview

The purpose of this study is to compare two regimens of low volume (2L) polyethylene glycol(PEG)plus ascorbic acid versus standard volume (4L) PEG alone for bowel preparation in out-patients

Inadequate bowel preparation may lead to a longer colonoscopy, and to an inability to identify lesions. PEG can provide a rapid orthograde peroral approach to colonic lavage without producing significant fluid or electrolyte changes. Thus PEG is now commonly used for bowel preparation. However, large amounts and unsatisfactory taste of PEG solution are generally poorly tolerated. a new low volume PEG-based bowel cleansing agents became available at foreign countries. Although several studies reported the efficacy and improved compliance of these low volume PEG plus ascorbic acid solution for colonoscopy, but result in Korean patients was not-recognized.

Study Type

OBSERVATIONAL

Enrollment

360

Conditions

Colonoscopy [E01.370.372.250.250.200]

Interventions

polyethylene glycol, ascorbic acidDRUG

comparison of different solutions for bowel preparation

Eligibility

Sex: ALLMin age: 19 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Out-patients for colonoscopy Exclusion Criteria: * age under 19 years or over 80 years * Intestinal obstruction * Women of pregnant, breastfeeding, or at risk of becoming pregnant * major psychiatric illness * known allergy to PEG * serious condition- severe cardiac, renal, or metabolic diseases * past history of colon resection * current acute exacerbation of chronic inflammatory bowel disease * functional constipation defined by Rome III diagnostic criteria

Locations (1)

Kangbuk Samsung Hospital

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

The efficacy of bowel preparation

three segmental preparation scoring (0\~4, Rt., mid, Lt.colon) total preparation grade:A,B,C,D (A or B was defined successful bowel cleansing) Influence of the intake of additional fluid in PEG+ascorbic acid

Time frame: one day (after colonoscopy)

Secondary Outcomes

Patient's compliance and acceptability

satisfaction (Visual Analogue Scale) amount of ingestion, frequency and amount of vomiting, tolerability, complication, taste

Time frame: one day (after injestion of preparation solution)

Data from ClinicalTrials.gov

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