ADenosine Vasodilator Independent Stenosis Evaluation II - ADVISE II

Inclusion Criteria: * \- Patient must be \> 18 and \< 85 years of age * Willing to participate and able to understand, read and sign the informed consent document before the planned procedure * Eligible for coronary angiography and/or percutaneous coronary intervention * Coronary artery disease with at least 1 or more visually assessed coronary stenoses (\>40% diameter stenosis) in native major epicardial vessel or its branches by coronary angiogram. * Stable angina or acute coronary syndromes (non-culprit vessels only and outside of primary intervention during acute myocardial infarction) Exclusion Criteria: * \- Known contraindication to adenosine administration * Implanted temporary or permanent artificial pacemakers, Left Bundle Branch Block (LBBB), 1st and 2nd degree AV Block * STEMI or non STEMI within 48 hours of procedure * Any contraindications for FFR interrogation or percutaneous coronary intervention (PCI) as determined by the investigator * Severe vessel tortuosity and/or severe calcification by angiogram * Significant valvular pathology (moderate or severe AS/AR/MS/MR) * Previous Coronary Artery Bypass surgery with patent grafts to the interrogated vessel * Weight \>200kg (441 lbs.) * Hemodynamic instability at the time of intervention (heart rate\<50 beats per minute, systolic blood pressure \<90mmHg) balloon pump * Significant hepatic disease, renal disease, lung disease (pulmonary chronic pulmonary obstructive disease) and/or malignant disease with unfavorable prognosis or presenting with abnormal serum laboratory values that the physician believes is clinically significant * Contraindication to antithrombotic regimen or anticoagulation therapy * History of or known reaction or sensitivity to contrast agent and is unable to be pre-medicated * Left main stenosis, tandem stenosis separated by more than 5 mm that require separate pressure guide wire interrogation or PCI (not to be interrogated or treated as a single stenosis), or total occlusions * Known Left ventricular ejection fraction (LVEF) \<30%