The overall purpose of the study is to investigate whether there is a relationship between 26 different single nucleotide polymorphisms (SNPs) in the vitamin D pathway, ultraviolet B (UV-B) irradiation of the skin and vitamin D status. The hypothesis is that vitamin D status are influated by different genetic genotypes in the vitamin D pathway.
In this study approximately 80 participants (over 18 years) are included. All the participants has previously participated in the VitmaD intervention study (NCT01184716) . Participants will in total receive 4 times UV-B irradiation (3 SED) with two day apart each time, to stimulate vitamin D production in the skin. The participants skintype will be measured. The study starts in January 2013 and runs to the end of Marts 2013. During this winter period, it is in Denmark not possible to produce vitamin D in the skin through sunlight exposure.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
102
Bispebjerg Hospital
Bispebjerg, Copenhagen, Denmark
DTU / National Food Institute
Mørkhøj, Søborg, Denmark
serum 25-hydroxyvitamin D
Measures the vitamin D status i serum at baseline and at the end of the project
Time frame: 10 days
Skintest
Optimize scientific; measures pigmentation and redness of the skin. Are measured at baseline and at end of project
Time frame: 10 days
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