Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

Charite University, Berlin, Germany20 enrolled

Overview

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Parkinson's Disease

Interventions

stationary bike exerciseBEHAVIORAL

aerobicBEHAVIORAL

Eligibility

Sex: ALLMin age: 35 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * UPDRS \<15 * L-DOPA responsive * \<5 yrs since diagnosis Exclusion Criteria: * severe other diseases * MMSE \< 26 * treatment with psychiatric medication

Locations (1)

Department of Neurology, Charité Universitätsmedizin Berlin

Berlin, State of Berlin, Germany

Outcomes

Primary Outcomes

UPDRS motor score

Time frame: Prior to intervention and after 6 months of intervention

Secondary Outcomes

Functional/Structural brain changes

Time frame: Prior to intervention and after 6 months of intervention

Plasma biomarkers

Time frame: Prior to intervention and after 6 months of intervention

Cognitive Function based on neuropsychological test-performance

Time frame: Prior to intervention and after 6 months of intervention

Data from ClinicalTrials.gov

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