Study of Anti-atherosclerotic and Estrogen-like Activity of Karinat in Perimenopausal Women

Inclusion Criteria: * Perimenopausal women aged 45 to 60 years with intact womb and ovaries * The absence of menstruations between 6 to 24 months * Last menstruation after the age of 40 years * Follicle-stimulating hormone (FSH) blood level ≥ 35 ng/ml * Mammography without nodal form of mastopathy or breast cancer signs * Absence of hypolipidemic therapy or HRT (hormone replacement therapy) during 6 months before the inclusion Exclusion Criteria: * Administration of lipid-lowering drugs, and/or HRT, and/or phytoestrogens during 6 month before inclusion * Personal history or diagnostic of following diseases: nodal form of mastopathy or breast cancer any cancer except non-melanoma skin cancer stroke or myocardial infarction chronic renal failure II-III chronic hepatic failure II-III liver cirrhosis chronic heart failure IIa-III exacerbation of chronic stomach or duodenal ulcer obesity (BMI \>30 kg/m2) alcohol abuse uncontrolled arterial hypertension (systolic blood pressure \> 160 mmHg, diastolic blood pressure \> 90 mmHg) current cigarette smoking (\>10 cigarettes a day) diabetes mellitus deep vein thrombosis or pulmonary embolism * Individual intolerance of Karinat or major side effects