Prevention of Postoperative Atrial Fibrillation

N/ACompletedNCT01742039

George Washington University160 enrolled

Overview

The primary aim of this study is to determine the safest and most effective therapeutic strategy to decrease the incidence of postoperative atrial fibrillation following cardiac surgery in an era with shorter ICU and hospital length of stay. A secondary goal is to evaluate the length of hospital stay associated with each treatment strategy.

Study Type

OBSERVATIONAL

Enrollment

160

Conditions

Postoperative Atrial Fibrillation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age \> or = to 18 years * sinus rhythm * undergoing either coronary artery bypass graft surgery (CABG), valvular heart surgery or a combined procedure Exclusion Criteria: * received a class-I or class-III antiarrhythmic agent in the past six months * had second or third degree heart block * had a resting heart rate of less than 50 beats per minute * had a systolic blood pressure less than 100 mmHg * had severe asthma or severe chronic obstructive pulmonary disease * had uncontrolled heart failure * had a serum aspartate aminotransferase or alanine aminotransferase concentration greater than four times the upper limit of normal

Locations (2)

George Washington University Hospital

Washington D.C., District of Columbia, United States

George Washington University

Washington D.C., District of Columbia, United States

Outcomes

Primary Outcomes

occurrence of atrial fibrillation

The primary endpoint of this study was also the occurrence of atrial fibrillation for any length of time requiring treatment as a result of symptoms or hemodynamic compromise.

Time frame: postoperative day 0-day of discharge (an average of 5 days)

occurrence of atrial fibrillation

The primary endpoint of this study was the occurrence of atrial fibrillation lasting longer than five minutes

Time frame: postoperative day 0-day of discharge (an average of 5 days)

Secondary Outcomes

length of stay

The secondary endpoint was the length of hospital stay after surgery.

Time frame: participants will be followed for the duration of hospital stay, an expected average of 5 days

Data from ClinicalTrials.gov

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