Early Hydration in Acute Myocardial Infarction

Ospedale Misericordia e Dolce300 enrolled

Overview

The purpose of this study is to determine whether hydration with sodium bicarbonate is more effective than hydration with sodium chloride to prevent contrast nephropathy in patients undergoing primary coronary intervention for acute ST elevation myocardial infarction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

300

Conditions

Contrast Induced Acute Kidney Injury

Interventions

sodium bicarbonate solutionDRUG

Isotonic salineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Consecutive patients with AMI candidates for primary PCI presenting within 12 h of symptom onset with ST-segment elevation of more 1 mm in at least two contiguous leads of electrocardiogram. Exclusion Criteria: * contrast medium administration within the 10 days * end-stage renal failure requiring dialysis * refusal to give informed consent

Locations (1)

Ospedale Misericordia e Dolce

Prato, Prato, Italy

Outcomes

Primary Outcomes

Incidence of contrast-induced acute kidney injury

contrast-induced acute kidney injury is defined as an increase in serum creatinine \>= 0.3 mg/dL over the baseline value within 2 days after the administration of the contrast medium

Time frame: 2 days

Secondary Outcomes

adverse clinical events

adverse clinical events within 1 month including in-hospital death and need for dialysis or hemofiltration

Time frame: 1 month

Data from ClinicalTrials.gov

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