Curative treatment for oesophageal cancer involves undertaking chemotherapy followed by an operation to remove the tumour. Chemotherapy has several effects upon the body, including effects upon the systems that control the creation and breakdown of muscle. We aim to review these effects by recording changes in the amount of exercise patients are able to undertake after chemotherapy and reviewing changes in muscle mass.
We aim to review the effects of chemotherapy on skeletal muscle mass and cardio-respiratory performance in patients with oesophageal adenocarcinoma. All patients will be assessed by a Consultant Anaesthetist and a medical member of the Research team before commencing chemotherapy and after finishing their course. These assessments include a nutritional assessment, performance status assessments, blood assays, dual energy X-ray absorptiometry (DEXA) scans, cardio-pulmonary exercise (CPEX) testing and a muscle biopsy.
Study Type
OBSERVATIONAL
Enrollment
25
all patients will undertake a full body DEXA scan before and after chemotherapy
All patients will have a muscle biopsy before and after chemotherapy
patients will undertake exercise in the form of an exercise bike whilst having their cardiac and ventilatory performance analysed. This will take place before and after neoadjuvant chemotherapy
Graduate Entry Medical School, University of Nottingham
Derby, Derbyshire, United Kingdom
muscle mass
variations in muscle mass during neoadjuvant chemotherapy
Time frame: 3 months
nutritional status
assess nutritional status post chemotherapy via serum protein levels.
Time frame: 3 months
all cause mortality
Evidence of mortality and relate this to aerobic ability.
Time frame: 3 months
mitochondrial function performance status
review changes in mitochondrial function after neoadjuvant chemotherapy
Time frame: 3 months
cardiorespiratory performance (peak VO2)
review changes in cardiorespiratory performance (peak VO2) after neoadjuvant chemotherapy
Time frame: 3 months
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