Peroral endoscopic myotomy (POEM) has recently been introduced as promising alternative to laparoscopic Heller myotomy for patients with idiopathic achalasia. Several technical modifications have been proposed but have not yet been tested in randomized trials.
Objective: To evaluate efficacy and safety of water-jet assisted POEM (WJ) versus the conventional technique (C). Interventions: Patients with achalasia diagnosed by symptoms, endoscopy and barium swallow eligible for POEM were randomized to either the use of Erbe Hybrid knife (WJ group) or the conventional technique using injection and triangle tip knife interchangeably (C group). Main outcome measurements: Procedure time in both groups; secondary outcomes were clinical efficacy and safety (bleeding complications, pneumothorax or pleural effusion requiring intervention)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Water-jet assisted POEM procedure was performed
POEM were performed by the use of conventional technique using injection and triangle tip knife.
Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China
RECRUITINGProcedure time in both groups
Time frame: during POEM procedure
clinical efficacy and safety
bleeding complications, pneumothorax or pleural effusion requiring intervention
Time frame: during hospital stay and up to 1 year
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