Ultrasound Guided Transversus Abdominis Plane Block With Ropivacaine vs Placebo for Abdominal Hysterectomy: a Double-blinded, Randomized Clinical Trial

Hvidovre University Hospital48 enrolled

Overview

A Prospective double-blinded randomized clinical trial to test the effect of transversus abdominis plane block on postoperative pain and opoid consumption after abdominal hysterectomy. Two groups of each 24 patients. All patients are given general anesthesia. The patients are randomized to have a ultrasound guided bilateral transversus abdominis plane block with either 2 x 20 ml 0,75 % ropivacaine or 2 x 20 ml of 0,9 saline. All patients are provided with a PCA for self administration of morphine. Pain score on visual analog scale, nausea and vomiting are monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively as well as the total consumption of morphine after 24 hours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain and Postoperative Morphine Consumption After Abdominal Hysterectomy

Interventions

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Assigned to elective abdominal hysterectomy * Must be able to understand and speak danish * Must be able to give verbal and written consent Exclusion Criteria: * Abuse of alcohol or medicin * Daily treatment with opoids or glucocorticoids * Allergy towards any kind of localanesthetic drug * Intolerance toward morphine * Psychiatric desease * Age below 18

Outcomes

Primary Outcomes

Total morphine consumption during first 24 hours postoperatively

Time frame: At 24 hours postoperatively

Secondary Outcomes

Postoperative pain by visual analog scale at

Monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively by one of the investigators at rest, when coughing and when walking

Time frame: Monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively