Genetic and Neural Predictors of Adolescent Depression

Adult Cohort A. MDD Mothers Cohort Inclusion Criteria: * Current or past Major Depressive Disorder * English as first language or English fluency * Biological daughter who meets inclusion/exclusion criteria for High Risk Female Adolescent B. Healthy Control Mothers Cohort Inclusion Criteria: * No history of psychopathology * English as first language or English fluency * Biological daughter who meets inclusion/exclusion criteria for Healthy Female Adolescent Adolescent Cohort General Inclusion Criteria for Adolescent Cohorts: * Female * Ages 12-14 * English as first language or English fluency * Right handed General Exclusion Criteria for Adolescent Cohorts: * Past or present diagnosis of Major Depressive Disorder * Past or present diagnosis of any anxiety disorder * Past or present diagnosis of Bipolar Disorder * Past or present diagnosis of ADHD * Presence of medical or neurological illness (head injury, loss of consciousness greater than 5 minutes, seizure) * Current use of psychotropic medication * Presence of any contraindication for MRI: * Cardiac pacemakers * Metal clips on blood vessels (also called stents) * Artificial heart valve, artificial arms, hands, legs, etc. * Brain stimulator devices * Implanted drug pumps * Ear or eye implants * Known metal fragments in eyes * Exposure to metal filings or shrapnel (sheet metal workers, welders, and others) * Other metallic surgical hardware in vital area * Certain tattoos with metallic ink * Certain IUDs containing metal * Certain transdermal (skin) patches such as: * NicoDerm (nicotine for tobacco dependence) * Transderm Scop (scopolamine for motion sickness) * Ortho Evra (birth control) * Positive urine pregnancy test C. High Risk Female Adolescent Additional Inclusion Criterion: • Biological daughter of participant in the MDD Mothers cohort D. Healthy Female Adolescent Additional Inclusion Criterion: • Biological daughter of participant in the Healthy Control Mothers cohort