Indomethacin Prophylaxis for Heterotopic Ossification After Surgical Treatment of Elbow Trauma

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's150 enrolled

Overview

Patients who present to our institution with a traumatic injury to their elbow who need operative management will be randomized to one of two groups; a treatment arm and a control arm. The treatment arm will receive a three-week postoperative course of indomethacin while the control group will not. We will follow both groups to assess whether or not indomethacin prophylaxis affects the rate of heterotopic ossification.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

150

Conditions

Elbow Trauma Requiring Operative Management

Interventions

Indomethacin and Pantoprazole

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Terrible Triad * Radial head fracture surgical treatment * Monteggia and Trans-olecranon Fracture Dislocations * Distal Biceps Tendon Injuries * Distal Humerus Fractures * Coronoid Fractures * Capitellar-Trochlear fractures * Olecranon Fractures Exclusion Criteria: * Associated Traumatic Brain Injury * Burn Injuries associated with elbow trauma * History of Gastric Ulcers * Documented allergies to any Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) * Severe Asthma * Previous operative fixation to affected elbow * Participation in other research study * Inability to speak / understand English

Outcomes

Primary Outcomes

change in post operative radiographic evaluation

AS a standard care patients will be routinely assess at three, six , twelve and twenty four months post-operatively.