Dry Eye Syndrome (DES) is a common condition that affects approximately 20% of adults aged 45 and older. Although several clinical tests for the diagnosis and monitoring of DES are available, currently no gold standard for the assessment of DES exists. It has, however, been hypothesized that the assessment of tear film osmolarity may be a new and promising approach of an objective and non-invasive method for diagnosis and monitoring of treatment success. Recently, a new commercially available instrument (TearLab®, OcuSens Inc, San Diego, USA) for the assessment of tear film osmolarity has been introduced. This instrument allows for the easy and non-invasive determination of tear film osmolarity. Unfortunately, no data about reproducibility are yet available. Consequently, the current study sets out to investigate the short time reproducibility of tear film osmolarity measurements using the TearLab® instrument.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
40
Measurement of the objective scattering index (OSI)
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Vienna, Austria
Coefficient of variation of tear film osmolarity after repeated measurements
Time frame: Measurement of tear film osmolarity 3 times daily within 30 minutes for 3 consecutive days
Subjective symptoms assessed using the OSDI test
Time frame: on the screening day
Tear break up time
Time frame: on 3 consecutive study days once a day
Schirmer I test
Time frame: on 3 consecutive study days once a day
OSI (Objective Scattering Index)
Time frame: on 3 consecutive study days once a day
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