Analysis of Body Composition in Patients With Hepatocellular Carcinoma in Radioablation

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Overview

Number of shows: 20 patients Track: A month with three visiting Intervention: Nutritional assessment including anthropometry, bioelectrical impedance, biochemical tests, Psychometric Hepatic Encephalopathy Score and Critical Flicker Frequency.

There will be a prospective, longitudinal, comparative. It included 20 patients diagnosed with hepatocellular carcinoma. As there are a finite number of active patients at the institute, and no studies with sample size well established, has seen a sample size of 20 patients. The duration of individual monitoring shall be one month to three visits (baseline, week 2 and week 4 after receiving the first radiofrequency ablation). Each visit will be a nutritional assessment including anthropometry, bioelectrical impedance, biochemical tests, Psychometric Hepatic Encephalopathy Score (PHES) and Critical Flicker Frequency (CFF). Anthropometric measures to be taken are weight, height and arm circumference average. Bioelectrical impedance will be using a single frequency impedance meter (425 to -50 KHz, Range 0 to 10,000) Bioelectrical Body Composition Analyzer Quantium II RJL Systems. The team measured the subjects' impedance, resistance, reactance and phase angle by Lean Body program provided by the manufacturer. Hepatic encephalopathy be evaluated by testing PHES and was measured CFF, also also be measured ammonium, tumor necrosis factor, IL-1, IL-6, IL-10, renin angiotensin aldosterone.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Conditions

Liver Carcinoma

Interventions

HCC under treatment with radioablationBEHAVIORAL

The evaluation will take place over a period of 30 days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a diagnosis of hepatocellular carcinoma, treatment-naive and who are referred to the radiology department for radioablation as first therapy. * Outpatients. * Willingness to participate in the project. Exclusion Criteria: * Patients with hepato-renal diseases. * Patients diagnosed with hepatocellular carcinoma undergoing chemoembolization treatment, or who have received more than one session radioablation. * Patients with depression or psychiatric illnesses * Patients who do not agree to participate in the project. Exclusion Criteria: * incomplete Applied Tests * disagreement of the person to perform any of the tests * monitoring Breach * Hospitalization or death after the first session radioablation.

Locations (1)

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Mexico City, D.f., Mexico

Outcomes

Primary Outcomes

Nutritional Status

Measured with the following parameters:body weight and height (to calculate BMI), triceps skinfold and mid-arm circumference (to calculated mid-arm muscle circumference, fat mass, fat free mass total, intracellular and extracellular body water obtained by bioelectrical impedance analysis and individual vectors obtained by bioelectrical impedance vector analysis.

Time frame: Participants will be evaluated for a month

Secondary Outcomes

Minimal hepatic encephalopathy

Assessed by psychometric Hepatic Encephalopathy (PHES) and Critical Flicker Frequency (CFF)

Time frame: Participants will be assessed for one month

Data from ClinicalTrials.gov

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