Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer

Konkuk University Medical Center80 enrolled

Overview

1. The incidence of differentiated thyroid cancer is increasing in Korea. A significant number of them experience severe hypothyroidism in preparation for radioactive iodine (RAI) therapy after total thyroidectomy. 2. Because the function of thyroid hormone is closely linked with lipid and glucose metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy may induce the changes of metabolic parameters. 3. We investigate the effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer.

1. Study design measurement of various parameters during hypothyroid state (before 1 month, the day and after 1 month of RAI therapy) 2. Measurements 1. Measurement of metabolic and cardiovascular parameters * glucose profiles : HbA1c, fasting glucose level * lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride * adipocytokines : retinol binding protein(RBP) * 4, leptin, resistin, adiponectin * markers of endothelial and cardiac function : high-sensitivity C-reactive protein(hsCRP), homocystein, B-type natriuretic peptide(BNP) * bone turnover markers : CTX, bone ALP 2. Scoring of symptoms and signs of hypothyroidism (Zulewski score) * symptoms * physical signs

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hypothyroidism

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * radioiodine therapy after total thyroidectomy in differentiated thyroid cancer * age over 18 Exclusion Criteria: * kidney failure, liver failure, heart failure * infection * inflammation * autoimmune disease * other chronic disease

Outcomes

Primary Outcomes

Changes of metabolic parameters

* glucose profiles : HbA1c, fasting glucose level * lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride * adipocytokines : retinol binding protein(RBP)4, leptin, resistin, adiponectin * markers of endothelial and cardiac function : high-sensitivity C-reactive - protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)

Time frame: Before 1month of radioiodine therapy, Day of radioiodine therapy, After 1 month of radioiodine therapy

Secondary Outcomes

Changes of bone turnover markers

* bone formation marker: bone ALP * bone resorption marker: CTX

Time frame: Before 1month of radioiodine therapy, Day of radioiodine therapy, After 1 month of radioiodine terapy