Anthropometric, Metabolic, Cardiovascular and Symptomatic Profile in Postmenopausal Women

University of Sao Paulo45 enrolled

Overview

The purpose of this study is to investigate anthropometric, metabolic, cardiovascular and symptomatic profiles in postmenopausal women.

When aging, the body composition changes, leading to a reduction of muscle mass and strength, and to an increase in total body fat. These body composition changes have especially been observed in postmenopausal women, due to the hormonal changes taking place. After the menopause, the gynoid fat distribution with fat deposits in the gluteo-femoral region changes to an android fat distribution with an increased upper body fat, especially in the abdominal region. These consequences of the menopause associated with a decrease in aerobic capacity and reduced total energy expenditure may lead to the metabolic syndrome (MetS). The aim of this study was to investigate the anthropometric, metabolic, cardiovascular and symptomatic profile in gynoid and android postmenopausal women.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Postmenopausal Disorder

Interventions

Clinical examsOTHER

Physiological and biochemical tests; quality of life questionnaire; body composition measurement

Eligibility

Sex: FEMALEMin age: 50 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Postmenopausal women * Caucasian * 50-60 years of age Exclusion Criteria: * Neurological disease * Pulmonary disease * Cardiac disease * Oncological disease * Musculotendinous or articular injuries * Hormone replacement therapy * Cigarette smoking

Locations (1)

Optics Group from Physics Institute of São Carlos (IFSC), University of São Paulo (USP)

São Carlos, São Paulo, Brazil

Outcomes

Primary Outcomes

Relationships between postmenopause and fat distribution

Anthropometric measurements: waist-to-hip ratio and body mass index

Time frame: Baseline

Secondary Outcomes

Comparison of aerobic capacity between android and gynoid postmenopausal women

Progressive aerobic testing on treadmill (Modified Bruce Protocol): estimated maximum oxygen consumption; metabolic equivalents; blood pressure; heart rate

Time frame: Baseline

Comparison of metabolic parameters between android and gynoid postmenopausal women

Biochemical tests: the serum level of estradiol, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, insulin and glucose

Time frame: Baseline

Comparison of quality of life between android and gynoid postmenopausal women

Menopause Rating Scale (MRS): somatic symptoms; psychological symptoms; urogenital-sexual problems

Time frame: Baseline

Comparison of the body composition between android and gynoid postmenopausal women

Body composition: bipolar electrical bioimpedance (body fat and lean mass) and skinfolds (triceps, subscapular, suprailiac, abdominal, anterior thigh, medial calf)

Time frame: Baseline

Data from ClinicalTrials.gov

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