A Study of LY2922470 in Healthy Participants and Participants With Diabetes

Inclusion Criteria: For all participants: * Must be a male, or a female who cannot become pregnant, and who is either a healthy participant, or who has type 2 diabetes * Have a screening body mass index (BMI) of at least 18.0 kilograms per square meter (kg/m\^2) * Have blood pressure, pulse rate, blood and urine laboratory test results acceptable for the study For participants with Type 2 Diabetes Mellitus (T2DM): * Do not have any change to their diabetes treatment (exercise with or without metformin) for at least 4 weeks prior to screening. * Have a glycated hemoglobin (HbA1c) value of greater than or equal to 6% and less than or equal to 11% at screening Exclusion Criteria: For all participants: * Are currently participating in another clinical study or completed one in the last 30 days * Are allergic to LY2922470 or other related drugs * Have a history of significant heart, lung, liver, kidney, stomach or brain disease, or have any medical problems which may cause an increased risk during the study * Have electrocardiogram (ECG) readings that are not suitable for the study * Are infected with hepatitis B * Are infected with human immunodeficiency virus (HIV) * Have donated more than 450 milliliter (mL) of blood in the last 3 months or if have donated any blood in the last month * Have a regular alcohol intake greater than 21 units/week (male), or 14 units/week (female), or are unwilling to stop alcohol as required by the study restrictions (1 unit = 360 mL of beer, or 150 mL of wine, or 45 mL of spirits) * Smoke more than 10 cigarettes per day or are not willing to abstain from smoking while at the clinic. For participants with T2DM: * Have had heart disease or stroke within 6 months before entering the study * Have health complications due to poorly controlled diabetes as shown by blood and urine laboratory test results or based on physical examination and medical assessment as determined by the study doctor * Have been hospitalized for poor control of diabetes (keto-acidotic episode) in the last 6 months * Have used insulin to control diabetes in the last 1 year * Show symptoms of high blood sugar, for example (e.g.), frequent urination, always feeling thirsty, or unexpected weight loss