The Management of Schizophrenia in Clinical Practice (MOSAIC)

Genentech, Inc.557 enrolled

Overview

This study is a disease-based registry designed to follow patients with a DSM-IV-TR (Diagnostic and Statistic Manual of Mental Disorders, Text Revision) diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder treated in usual care settings for up to 5 years. The registry seeks to describe the course of disease in schizophrenia, including cognitive function and negative symptoms, its treatment, and its burden of disease for participants, caregivers, clinicians, and society as a whole.

Study Type

OBSERVATIONAL

Enrollment

557

Conditions

Schizophrenia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients, \>/= 18 years of age * DSM-IV-TR diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder * Participants presenting with the normal course of care in usual treatment settings * Able to read and speak English * Able and willing to provide informed consent * Able and willing to comply with the study protocol Exclusion Criteria: * Participants enrolled as subjects in clinical trials at registry enrollment * Participants anticipating they will be unable to participate in regularly scheduled assessments as per protocol

Locations (44)

Outcomes

Primary Outcomes

Positive and Negative Symptoms of Schizophrenia (PANSS)

Time frame: up to 5 years

Clinical Global Impression Schizophrenia Scale (CGI-SCH)

Time frame: up to 5 years

Cognitive function (Fluency, Digit Symbol-Coding, Trail Making Test)

Time frame: up to 5 years

Secondary Outcomes

Negative Symptom Assessment Scale (NSA4)

Time frame: up to 5 years

Pharmacologic/behavioural treatments used in usual care settings: intervention

Time frame: up to 5 years

Pharmacologic/behavioural treatments used in usual care settings: dose

Time frame: up to 5 years

Pharmacologic/behavioural treatments used in usual care settings: duration

Time frame: up to 5 years

Personal and Social Performance (PSP)

Time frame: up to 5 years

Schizophrenia Quality of Life Scale (SQLS)

Time frame: up to 5 years

Schizophrenia Caregiver Questionnaire

Time frame: up to 5 years

Maslach Burnout Inventory (MBI)

Time frame: up to 5 years

Data from ClinicalTrials.gov

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Unnamed facility

Granada Hills, California, United States

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Los Angeles, California, United States

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Santa Monica, California, United States

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Cedar Rapids, Connecticut, United States

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New Haven, Connecticut, United States

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Chicago, Florida, United States

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Gainesville, Florida, United States

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Gainesville, Florida, United States

Unnamed facility

Gainesville, Florida, United States

Unnamed facility

Jacksonville, Florida, United States

...and 34 more locations