The investigators plan to compare epidurals versus wound catheters for effects on pain relief and recovery following open liver surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
97
Wound catheter, placed at end of procedure, prior to closure. To be kept in for 48 hours.
Royal Infirmary of Edinburgh
Edinburgh, Lothian, United Kingdom
Length of stay
Number of days (to nearest half day) patients stay in hospital.
Time frame: Measurement made on day of discharge which is expected to be on average bewteen 5 and 10 days after surgery.
Pain Scores
Visual analogue scores of pain experienced.
Time frame: Performed daily at 0900 hours. On the day of surgery pain scores will be performed at 2, 6 and 12 hours post surgery.
Molecular response to surgery
HMGB1, RAGE and cytokines
Time frame: Days 0, 1 and 3
Central Venous Pressure
Mean Central Venous Pressure during liver transection will be quantified and compared between groups.
Time frame: During liver transection
Estimated Blood Loss
Time frame: Intra-operative
Operative field asessment
Time frame: During liver transection
Pringle time
Time frame: Intra-operative
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