Cabazitaxel in Platinum Refractory Ovarian Cancer

Inclusion Criteria: * Histologically confirmed epithelial, primary fallopian or primary peritoneal cancer. Stages I-IV. * Patients with refractory disease defined as progression or no change during primary treatment, as evaluated after 3 and/or 6 cycles of platinum/paclitaxel. Prior to inclusion, patients must have received platinum and paclitaxel as combination treatment. * Measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or evaluable by Gynecologic Cancer Interest Group (GCIG) cancer antigen 125 (CA-125) criteria. * Age ≥ 18 years. * Performance stage 0-2. * Adequate bone marrow function, liver function, renal function, and coagulation parameters (within 7 days prior to inclusion): 1. Neutrophils (ANC) ≥ 1.5 x 10\^9/l 2. Platelet count ≥ 100 x 10\^9/l 3. Serum bilirubin ≤ 1.0 x upper limit of normal (ULN) 4. Serum transaminase ≤ 2.5 x ULN 5. Serum creatinine ≤ 1.5 ULN. If creatinine 1.0 - 1.5 x ULN, creatinine clearance will be calculated according to the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI)and patients with creatinine clearance \<60 mL/min should be excluded * Written informed consent. Exclusion Criteria: * History of severe hypersensitivity reaction (≥grade 3) to taxol. * History of severe hypersensitivity reaction (≥grade 3) to polysorbate 80 containing drugs. * Concurrent or planned treatment with strong inhibitors or strong inducers of cytochrome P4503A4/5 (a one week wash-out period is necessary for patients who are already on these treatments). * Neuropathy grade ≥ 2. * Pregnant or breast-feeding patients. For fertile women a negative pregnancy test at screening is mandatory. * Fertile patients not willing to use effective methods of contraception during treatment and for 6 months after the end of treatment. * Other malignant diseases within 5 years prior to inclusion in the study, except basal cell or squamous cell carcinoma of the skin and cervical carcinoma-in-situ. * Other experimental therapy or participation in another clinical trial within 28 days prior to treatment initiation. * History of any chronic medical or psychiatric condition or laboratory abnormality that is not medically controlled or in the opinion of the investigator may increase the risks associated with study drug administration. (e.g. diabetes, cardiac diseases, hypertension, renal, thyroid or liver disease). * Vaccination with yellow fever vaccine or any live attenuated vaccine during the treatment. * Treatment with disulfiram (antabuse)