The aim of this study is to estimate the burden of disease due to pneumococci, other bacteria and viruses in the African meningitis belt prior to pneumococcal conjugate vaccine introduction and to estimate the population impact of the vaccine after its implementation in 2014. In a defined population of a sanitary district in northern Togo, during the period 2010 to 2017, investigators enroll patients of all ages with suspected pneumonia requiring hospitalization or suspected bacterial meningitis. Patients are evaluated by bacteriology and molecular biology techniques on blood, cerebro-spinal fluid, nasal aspirates and by chest X-ray.
Study Type
OBSERVATIONAL
Enrollment
2,000
Centre Hospitalier Régional (CHR) Savanes
Dapaong, Savanes, Togo
RECRUITINGClinique Win' Pang
Dapaong, Savanes, Togo
RECRUITINGHôpital d'enfants Yendubé
Dapaong, Savanes, Togo
RECRUITINGPolyclinique
Dapaong, Savanes, Togo
RECRUITINGCentre médico-social (CMS)
Sinkassé, Savanes, Togo
RECRUITINGIncidence of pneumococcal pneumonia requiring hospitalisation, confirmed by blood culture or PCR analysis of blood
Time frame: Subjects will be enrolled on admission to hospital and followed for the duration of hospitalization (median duration 6 days)
Incidence of pneumococcal meningitis, confirmed by culture or PCR on cerebro-spinal fluid
Time frame: Subjects will be enrolled on admission to hospital and followed for the duration of hospitalization (median duration 6 days)
Incidence of radiologically confirmed pneumonia requiring hospitalisation
Time frame: Subjects will be enrolled on admission to hospital and followed for the duration of hospitalization (median duration 6 days)
Incidence of suspected pneumonia requiring hospitalisation with elevated C-reactive protein serum concentration (<40mg/l)
Time frame: Subjects will be enrolled on admission to hospital and followed for the duration of hospitalization (median duration 6 days)
Incidence of suspected pneumonia requiring hospitalisation with reduced oxygen saturation (<90%)
Time frame: Subjects will be enrolled on admission to hospital and followed for the duration of hospitalization (median duration 6 days)
Incidence of pneumonia of other bacterial or viral etiology requiring hospitalisation
Time frame: Subjects will be enrolled on admission to hospital and followed for the duration of hospitalization (median duration 6 days)
Incidence of acute meningitis of other bacterial etiology
Time frame: Subjects will be enrolled on admission to hospital and followed for the duration of hospitalization (median duration 6 days)
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