The Realtime Detection for Individual Variation of Analgesic ：A Comparison of Sufentanil vs Fentanyl

Huazhong University of Science and Technology120 enrolled

Overview

Purpose: This study aimed to find a quick and timely way to investigate the individual variation of efficacy of opioid analgesic in Chinese patients undergoing elective surgeries. Methods: 120 female patients receiving elective surgery under general anesthesia were recruited into this study. At the time of routine intravenous anesthetic induction we observe the efficacy of opioid analgesic including analgesic effect, effects on Narco-trend index, sedative effect, effects on respiratory system, and aslo effects on cardiovascular system.

Patients with the following diseases were excluded: known history of chronic pain, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, pregnancy or at the lactation period.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Surgery Individuality

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 20-65 years * Anesthesiologists (ASA) physical status I or II; * Within ±20% of ideal body weight; * Agreed to participate the research Exclusion Criteria: * History of chronic pain; * Psychiatric diseases; * Diabetes mellitus; * Severe cardiovascular diseases; * Kidney or liver diseases; * Alcohol or drug abuse (according to the criteria of DSM-IV); * Pregnancy or at lactation period; * Disagree to participate to the research

Outcomes

Primary Outcomes

Mean Pressure Pain Threshold

According to the measurement of pressure pain threshold after intravenous injection of opioid analgesics