The investigators use bicarbonate injected to an intravenous line and the changes in the exhaled end-tidal carbon dioxide to verify whether the IV line is in the vein or surrounding tissue
The method was proved useful in previous phase I, II studies. Now the investigators move on to assess the method in a phase III study in oncological patients. each patients which will be subjected to intravenous chemotherapy will be eligible ( see also inclusion/exclusion criteria). Once consent obtained the patient will have an IV line placed. each line placed will be categorized by the clinical team into 3 categories: 1. IV in place ready to use for chemotherapy ( good blood return) 2. Doubtful position ( no blood return/ little blood return bu flushes well). 3. IV not in place. Study design Category 1. IV bicarbonate 4.2% 20 cc and NS 20 cc in a randomized fashion Category 2. same as above Category 3. No injections
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
100
Sheba Medical Center Oncology
Tel Litwinsky, Israel, Israel
RECRUITINGOncology Clinic
Tel Litwinsky, Israel
NOT_YET_RECRUITINGchange in exhaled end tidal co2
the injection of bicarbonate in a vein cause a rapid and distinct change in exhaled end-tidal CO2
Time frame: 1-3 minutes
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