Evaluation of 24-hour antihypertensive effect of long-acting ARB-CCB tablet administrated to hypertensive patients with atrial fibrillation, and comparison of 24-hour antihypertensive effect of long-acting ARB-CCB tablet between morning administration and bedtime administration.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
Oral-administration of one telmisartan-amlodipine tablet once a day upon morning for 12 weeks
Oral-administration of one telmisartan-amlodipine tablet once a day at bedtime for 12 weeks
Uchiyama Clinic
Jōetsu, Niigata Pref., Japan
RECRUITINGChange in 24-hour average blood pressure from baseline to Week 12.
Time frame: Baseline and 12 weeks.
Change in blood pressures at night time, early-morning, and daytime from baseline to Week 12.
Time frame: Baseline and 12 weeks.
Change in blood pressure at hospital visit from baseline to Week 12.
Time frame: Baseline and 12 weeks.
Change in blood pressure at home from baseline to Week 12.
Time frame: Baseline and 12 weeks.
Change in blood pressure control rate from baseline to Week 12.
Time frame: Baseline and 12 weeks.
Change in blood pressure variability from baseline to Week 12.
Time frame: Baseline and 12 weeks.
Change in laboratory parameters (blood insulin, hsTnT, PAI-1, and NT-ProBNP) from baseline to Week 12.
Time frame: Baseline and 12 weeks.
Onset of Adverse events
Time frame: Baseline and 12 weeks.
Onset of atrial fibrillation
Time frame: Baseline and 12 weeks.
Pulse rate
Time frame: Baseline and 12 weeks.
PWV value
Time frame: Baseline and 12 weeks.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Clinical laboratory test results
Time frame: Baseline and 12 weeks.