The purpose of this study is to determine the effect of fluid restriction and the neurohormonal mechanisms in the development of hyponatremia in patients with congestive heart failure and hyponatremia. The hypothesis is that strict fluid restriction leads to a larger increase in plasma sodium than standard treatment in patients with decompensated heart failure associated with hyponatremia. A secondary hypothesis is that the neurohormonal change is greater in patients treated with strict fluid restriction versus standard treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Patients will be randomized to strict fluid restriction \< 1 L/day versus moderate fluid restriction \< 2.5 L/day
Department of Cardiology, Copenhagen University Hospital, Rigshospitalet
Copenhagen, Denmark
RECRUITINGBispebjerg Hospital
Copenhagen, Denmark
RECRUITINGChange in plasma sodium from day 1 to day 4: - Normalization of plasma sodium or - A significant change in plasma sodium of a minimum of 5 mmol/L from baseline to day 4
Time frame: 5 days
Change in plasma vasopressin and copeptin
Time frame: 5 days
Change in blood pressure, heart rate, weight and oedemas
Time frame: 5 days
Change in dyspnoea assessed by the patient
Time frame: 5 days
Number of days until clinical stability
Time frame: 5 days
The correlation between hospitalization time and plasma sodium
Time frame: 5 days
Correlation between fluid restriction and change in kidney function
Time frame: 5 days
Patient assessment of fluid restriction
Time frame: 5 days
Patient compliance to fluid restriction
Time frame: 5 days
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