Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil capsule orally for 12 weeks to examine its effectiveness in reducing body arsenic load and clinical symptoms. Similar treatment with similar number of arsenic exposed controls and healthy volunteers will be included for comparison.
Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition. Till today there is no effective treatment. Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of this study is to examine the effectiveness of oral administration of garlic oil to reduce body arsenic load and clinical symptoms of arsenical palmer keratosis.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Oral administration
Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh
Change in the clinical symptom of keratosis in palm
Time frame: 0 week (baseline) to 12 weeks (end)
Change in biochemical parameters (blood sugar, cholesterol and transaminase) after treatment
Time frame: 0 week (baseline), 12 weeks (end)
Adverse effects following treament
Time frame: 0 week (baseline), 12 weeks (end)
Change in the amount of arsenic in nail
Time frame: 0 week (baseline), 20 weeks (end)
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