Women of reproductive age are considered a high-risk group for worm infections by the World Health Organization. Maternal infection and anemia contribute to infant malnutrition by affecting milk quality and quantity, and duration of exclusive breastfeeding. To date, no study has investigated the health benefits of postpartum deworming to infants or mothers. A randomized controlled trial will be conducted in Peru to investigate the effectiveness of integrating deworming into routine postpartum care. The primary measure of effect will be infant weight gain between birth and six months of age. Other infant and maternal health indicators will also be ascertained.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
1,010
Asociación Civil Selva Amazónica
Iquitos, Peru
Mean (± standard deviation) weight gain (kg)
Time frame: Change between birth and six months of age
Infant morbidity
Time frame: 1, 6, 12, 24 months following birth
Maternal hemoglobin levels and anemia
Time frame: 1, 6, 12, 24 months following birth
Breastfeeding practices
The prevalence of current, exclusive, predominant and partial breastfeeding will be used to assess breastfeeding practices. In accordance with WHO criteria, infants will be considered as exclusively breastfed if they ingest only breast milk (excluding vitamins and medications); considered as predominantly breastfed if, in addition to breast milk, they also ingest water, juice, teas, vitamins or medications, and considered as partially breastfed if their primary nutrition source is other than breast milk.
Time frame: 1, 6, 12, 24 months following birth
Maternal energy levels
Maternal energy levels will be measured using an adapted 5-item version of the Fatigue Assessment Scale (FAS) (Michielsen et al. 2004). This scale assesses symptoms of physical and cognitive fatigue.
Time frame: 1, 6, 12, 24 months following birth
Maternal STH infection
Time frame: 1 and 6 months following birth
Breast milk quality
Mean concentrations of key breast milk quality indicators (i.e. macronutrients, immunological factors, vitamins, and minerals) will be used to assess breast milk quality.
Time frame: 1 and 6 months following birth
Breast milk quantity transferred from mother to infant
Time frame: 1 and 6 months following birth
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