Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse

Turku University Hospital78 enrolled

Overview

The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).

The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus. The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pelvic Organ Prolapse

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * surgery for pelvic organ prolapse * hysterectomy due to other benign reasons than pelvic organ prolapse Exclusion Criteria: * surgery due to malignancy

Locations (1)

Department of Obstetrics and Gynecology, Turku University Central Hospital

Turku, Finland

Outcomes

Primary Outcomes

The elastin content in tissue samples in patients with or without pelvic organ prolapse.

Time frame: september 2012

Secondary Outcomes

The collagen content in tissue samples in women with or without pelvic organ prolapse.

Time frame: September 2012

Data from ClinicalTrials.gov

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