Single blind randomized clinical trial including 50 stroke patients to investigate the effect of daily music listening on behavioral, neural and physiological recovery. Patients are randomized (1:1:1) to listen instrumental or vocal music, or audiobooks (recorded book reading) (control). Outcome measures are change in neuropsychological tests, change in self-reported mood, structural and functional magnetic resonance imaging changes and hormonal changes performed at acute, 3-month and 6-month stages.
Please see above
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
50
Turku University Hospital
Turku, Finland
Change in neuropsychological performance (verbal memory)
Verbal memory summary score (Rivermead Behavioral Memory Test (RBMT) story recall, auditory-verbal learning task)
Time frame: From acute to 3-month-stage
Change in neuropsychological performance (verbal memory)
Verbal memory summary score (RBMT story recall, auditory-verbal learning task)
Time frame: From acute to 6-month-stage
Change in neuropsychological performance (Language skill)
Verbal fluency task
Time frame: From acute to 3-month-stage
Change in neuropsychological performance (Language skill)
Naming test CERAD/Boston Naming Test (BNT)
Time frame: From acute to 3-month-stage
Change in neuropsychological performance (Language skill)
Short Token Test
Time frame: From acute to 3-month-stage
Change in neuropsychological performance (Language skill)
Verbal fluency task
Time frame: From acute to 6-month-stages
Change in neuropsychological performance (Language skill)
Naming test CERAD/BNT
Time frame: From acute to 6-month-stages
Change in neuropsychological performance (Language skill)
Short Token Test
Time frame: From acute to 6-month-stages
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Change in mood
Profile of Mood States
Time frame: From acute to 3-month-stage
Change in mood
Profile of Mood States
Time frame: From acute to 6-month-stage
Change in structural gray matter
Voxel-based morphometry
Time frame: From acute to 3-month-stage
Change in structural gray matter changes
Voxel-based morphometry
Time frame: From acute to 6-month-stage
Change in structural white matter
Diffusion-weighted imaging
Time frame: From acute to 3-month stage
Change in structural white matter
Diffusion-weighted imaging
Time frame: From acute to 6-month stage
Change in neuronal function
Resting state/task-based fMRI
Time frame: From acute to 3-month stage
Change in neuronal function
Resting state/task-based fMRI
Time frame: From acute to 6-month stage
Change in physiological stress level
Cortisol serum concentration
Time frame: From acute to 3-month-stage
Change in physiological stress level
Cortisol serum concentration
Time frame: From acute to 6-month-stage
Change in physiological stress level
Beta-endorphin serum concentration
Time frame: From acute to 3-month-stage
Change in physiological stress level
Beta-endorphin serum concentration
Time frame: From acute to 6-month-stage
Change in physiological stress level
Oxytocin serum concentration
Time frame: From acute to 3-month-stage
Change in physiological stress level
Oxytocin serum concentration
Time frame: From acute to 6-month-stage