The Study of Breast MRI Screening and Proton Magnetic Resonance Spectroscopy

National Taiwan University Hospital270 enrolled

Overview

To delineate if the chemical composition (lipid and water) in the presumably normal breast of the high risk women is different from those of the low risk group.

The researchers would like to investigate and compare the chemical composition in the normal breast between high risk women and general population.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

270

Conditions

Breast Diseases

Interventions

proton magnetic resonance spectroscopyPROCEDURE

proton magnetic resonance spectroscopy was performed for the normal breast to evaluate the chemical composition of breast

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women without breast symptoms (without family history of breast cancer; or with at least first-degree relative of breast cancer) with negative mammography and ultrasound result in recent 3 months or contralateral normal breasts from women with newly diagnosed unilateral breast cancer * 25-75 years old. Exclusion Criteria: * renal function impairment * past history of anaphylactoid reaction to MRI contrast media (Gd-DTPA) * pregnant or lactating women * medication of HRT or oral pills in recent 6 months * past history of surgery of the breast (either side) * past history of breast cancer * with breast implant or silicone injection * past history of cardiac surgery, mechanical valve replacement, aneurismal clip, endotracheal tube or tracheostomy tube, any metallic implants.

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

comparison of lipid water composition and ratio of the normal breasts in women of high risk group and low risk group.

This is a cross sectional study. And we just assess the chemical composition of normal breasts of women at a given time point, since the participants only received one time of study.

Time frame: up to 5 years ( July 2008 to June 2013)

Secondary Outcomes

to investigate the association between breast density and lipid water ratio of normal breasts

to investigate whether there is association of breast density and chemical composition of normal breast on proton magnetic resonance spectroscopy.

Time frame: up to 5 years (July 2008 to June 2013)

to investigate the association between menopausal status and lipid water ratio of normal breasts

to investigate whether there is association of menopausal status and chemical composition of normal breast on proton magnetic resonance spectroscopy.

Time frame: up to 5 years ( July 2008 to June 2013)

Data from ClinicalTrials.gov

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