Comparing the Safety and Efficacy of BOL-303259-X Ophthalmic Solution With Timolol Maleate Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension

Inclusion Criteria: * Participants must have a diagnosis of OAG (including pigmentary or pseudoexfoliative) or OHT in 1 or both eyes. * Participants must meet the following IOP requirements at Visit 3 * mean/median IOP ≥ 24 mmHg at a minimum of 2 time points in the same eye * IOP ≤ 36 mmHg at all 3 measurement time points in both eyes. * Participants with a best-corrected visual acuity (BCVA), using the Early Treatment of Diabetic Retinopathy Study (ETDRS) protocol, of +0.7 logMAR units (Snellen equivalent of approximately 20/100) or better in either eye. Exclusion Criteria: * Participants with known hypersensitivity or contraindications to latanoprost, NO treatment, timolol maleate, other beta-adrenergic receptor antagonists or any of the ingredients in the study drugs. * Participants with a central corneal thickness greater than 600 μm in either eye. * Participants with advanced glaucoma and participants with a cup/disc ratio greater than 0.8 or a history of split fixation, or a field loss threatening fixation in either eye. * Participants who do not have an intact posterior capsule in either eye . * Participants with aphakia in either eye. * Participants with previous or active corneal disease in either eye. * Participants with current or a history of severe dry eye in either eye. * Participants with current or a history of optic disc hemorrhage in either eye. * Participants with current or a history of central/branch retinal vein or artery occlusion in either eye. * Participants with current or a history of macular edema in either eye. * Participants with very narrow angles (3 quadrants with less than Grade 2 according to Shaffer's anterior chamber angle grading system) and participants with angle closure,congenital, and secondary glaucoma, and participants with history of angle closure in either eye. * Participants with a diagnosis of a clinically significant or progressive retinal disease in either eye. * Participants with any intraocular infection or inflammation in either eye within 3 months(90 days) prior to Visit 1 (Screening). * Participants with a history of ocular laser surgery in either eye within the 3 months(90 days) prior to Visit 1 (Screening). * Participants with a history of incisional ocular surgery or severe trauma in either eye within 3 months (90 days) prior to Visit 1 (Screening).