A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD

Inclusion Criteria: * Age greater than 18 years. * Estimated glomerular filtration rate (eGFR) ≤ 45 ml/min/1.73m2 but ≥20 mL/min/1.73m2. * Poorly controlled blood pressure by 24-hour ambulatory blood pressure (BP) monitoring. * Treated hypertension: use of at least one antihypertensive drug. One of the drugs should be either an angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB). If these are contraindicated then use of a beta-blocker is required. Exclusion Criteria: * Use of thiazide or thiazide-like drugs in the previous 3 months. * Use of furosemide in a dose \>200 mg/d. * Ambulatory BP of either ≥160 systolic or ≥100 mmHg by 24-hour ambulatory BP monitoring. * Expected to receive renal replacement therapy within the next 3 months. * Vascular event such as myocardial infarction, heart failure hospitalization, or stroke within 3 months prior to randomization. * Pregnant or breastfeeding women or women who are planning to become pregnant or those not using a reliable form of contraception (oral contraceptives. condoms and diaphragms will be considered reliable). * Known hypersensitivity to thiazide or sulfa drugs. * Organ transplant recipient or therapy with immunosuppressive agents. Nasal or inhaled corticosteroids will be permitted.