Modulation of Mucosal and Systemic Immunity by Hormonal Contraceptives

Inclusion Criteria: 1. 15-25 years of age (inclusive) 2. History of regular menstrual cycle 3. Not pregnant 4. No plan to become pregnant in the next 3 months 5. Interested in beginning use of OC, DMPA, or LNG-IUD 6. Able to read and provide written informed consent (and consent from a parent/guardian if the participant is a minor) Exclusion Criteria: 1. Anticipated move out of area that prevents return for a follow-up visit 2. Unavailability for follow-up visit 3. Less than 90 days post-partum or post-abortion 4. Sexually transmitted infection (STI) diagnosed less than 30 days prior to enrollment 5. Use of OC, contraceptive ring or patch, single rod implant, LNG-IUD, or copper-containing IUD less than 3 months prior to enrollment 6. DMPA injection less than 6 months prior to enrollment 7. History of immunosuppressive condition of current use of immunosuppressive medications 8. History of a cervical malignancy 9. Detection of cervical anatomic pathologic conditions that preclude cervical biopsy procurement 10. Intolerance or contradiction to use of OC, DMPA, or LNG-IUD