AC105 in Patients With Acute Traumatic Spinal Cord Injury

Inclusion Criteria: * Male or female between 18 and 65 years of age, inclusive * Acute traumatic SCI, at a neurological level between C4 and T11 * No evidence of penetrating or transection injury (e.g. caused by projectile or stab wound) * Neurological ASIA Impairment Scale A, B or C * Patient is able to provide written or verbal witnessed consent. If unable to provide either, consent may be provided by legally authorized representative (LAR) * Patient is able to initiate treatment within time window of injury Exclusion Criteria: * Known allergy or hypersensitivity to polyethylene glycol * Mental impairment or other conditions that would preclude a reliable ASIA exam or adequate consent * Positive urine pregnancy test result * Serum creatinine level ≥ 2 mg/dL * History or active renal failure or dialysis * Mean arterial blood pressure \< 60 mmHg despite vasopressor treatment * On a current regimen of digoxin * Chronic use of magnesium salts prior to the SCI (within 1week of presentation) and/or the use of magnesium salts in the acute care setting prior to the administration of investigational product * Any other medical condition that, in the judgment of the investigator, would preclude provision of informed consent, make participation in the study unsafe, or unreasonably complicate follow-up or the interpretation of study outcome data or may otherwise interfere with achieving the study objectives * In the judgment of the Investigator, cannot adequately provide informed consent, is likely to be non-compliant, or may be unable to cooperate with study requirements