Background: Colonoscopy is often regarded as a painful and unpleasant procedure. Transcutaneous Electric Nerve Stimulation on Acupoints (Acu-TENS) is a non-invasive modality that has been used successfully to treat pain of various origins, but few good-quality studies have evaluated its role in treating pain and anxiety during colonoscopy. Objective: To investigate the efficacy of Acu-TENS in reducing procedure-related pain and the consumption of sedatives/analgesics during colonoscopy. Design: Prospective, randomized, placebo-controlled study. Subjects: One hundred and twenty eight consecutive patients undergoing first-time elective day-case colonoscopy without previous experience of acupuncture/Acu-TENS will be recruited. Interventions: Patients will be randomized to receive either 45 minutes of Acu-TENS or placebo-TENS before colonoscopy. The acupoints relevant to the treatment of abdominal pain and distension, including Zusanli, Hegu, Neiguan, Tianshu, and Dachangshu will be used. For the placebo-TENS group, a non-conductive plastic film will be placed between the acupoint and the electrode so that no current will be transmitted. Acu-TENS and placebo-TENS will be continued throughout colonoscopy. A mixture of Propofol and Alfentanil, delivered by a patient-controlled syringe pump, will be used for sedation/analgesia in both groups. Outcome measures: Primary outcome: doses of patient-controlled sedation/analgesia consumed. Secondary outcomes: pain and satisfaction scores according to a visual analog scale, cecal intubation rate/time, and episodes of hypotension/desaturation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
135
Patients randomized to the experimental group will receive Acu-TENS on acupoints relevant to the treatment of abdominal pain and distension, including Zusanli (stomach meridian ST-36), Hegu (large intestine meridian LI-4), Neiguan (pericardium meridian PC-6), Tianshu (stomach meridian ST-25), and Dachangshu (bladder meridian BL-25).
Patients randomized to the control group will receive placebo-TENS at the same acupoints.
Prince of Wales Hospital, The Chinese University of Hong Kong
Hong Kong SAR, China
Dose of patient-controlled sedation/analgesia consumed
Time frame: During the procedure (up to 1 day)
Pain score
Using a 10-cm unscaled visual analog scale; 0 = no pain, 10 = very painful
Time frame: During the procedure (up to 1 day)
Patients' satisfaction score
Using a 10-cm unscaled visual analog scale; 0 = not satisfied, 10 = very satisfied
Time frame: During the procedure (up to 1 day)
Patients' willingness to repeat the procedure
Time frame: Up to 1 day
Endoscopists' satisfaction score
Using a 10-cm unscaled visual analog scale; 0 = not satisfied, 10 = very satisfied
Time frame: During the procedure (up to 1 day)
Cecal intubation rate
Complete colonoscopy is defined as identification of ileocecal valve
Time frame: During the procedure (up to 1 day)
Cecal intubation time
The time from introduction of the colonoscope to the cecum
Time frame: During the procedure (up to 1 day)
Total procedure time
Time frame: During the procedure (up to 1 day)
Episodes of hypotension
Defined as systolic blood pressure \<90 mmHg
Time frame: During the procedure (up to 1 day)
Episodes of desaturation
Defined as SaO2 \<90%
Time frame: During the procedure (up to 1 day)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.