Identification of a Plasma Proteomic Signature for Lung Cancer

Inclusion Criteria: * age ≥ 40 * any smoking status, e.g. current, former, or never * co-morbid conditions, e.g. COPD * Nodule size ≥ 4 mm and ≤ 30 mm (up to Stage 2B eligible), any spiculation or ground glass opacity * Pathology: malignant - adenocarcinoma, squamous, or large cell * Pathology: benign - inflammatory (e.g. granulomatous, infectious) or non-inflammatory (e.g. hamartoma) * Clinical stage, Primary tumor: ≤T2 (e.g. 1A, 1B, 2A and 2B) * Clinical stage, Regional lymph nodes: N0 or N1 only * Clinical stage, Distant metastasis: M0 only Exclusion Criteria: * prior malignancy within 5 years of lung nodule diagnosis * No nodule size available * No pathology data available for those with * Current diagnosis of non-small cell lung cancer * Clinical stage: Primary tumor ≥T3; Regional lymph nodes: ≥N2; 4 Distant metastasis: ≥M1